Mental Health

Study overview This study applied a two-sample MR design with publicly available summary-level data taken from meta-analyses of genome-wide association studies (GWASs) as well as the FinnGen study, which was not included in any of the GWAS meta-analyses (Fig. 1). Outcomes included in this study were anorexia nervosa, bipolar disorder, MDD, and schizophrenia. Brief information about the used data sources for plasma caffeine and outcomes are described below. More comprehensive details for each GWAS are described in the corresponding articles [9,10,11,12,13,14]. Fig. 1 Study design overview (created with BioRender.com). AHR, aryl hydrocarbon receptor; CYP1A2, cytochrome P450 1A2 (CYP1A2); GWAS, genome-wide association study Full size image Data sources Plasma caffeine GWAS Cornelis et al. performed a meta-analysis of summary statistics from six plasma caffeine (1,3,7-trimethylxanthine) GWASs comprising 9876 participants of mainly European ancestry, with mean ages between 47 and 7...

Bipolar disorders are often associated with creativity and other positive personality attributes. Some researchers want to explore these links to find better treatment protocols. Living with bipolar disorder can mean experiencing shifts in mood and energy levels. The label actually refers to a group of conditions that involve episodes of high or low excitability or irritability, often interfering with daily life. Personality traits are important for researchers in at least two ways. People with a bipolar disorder diagnosis may be more likely to have some of the "big five" personality traits, such as neuroticism. Also, understanding that people with a diverse range of personality traits may also have bipolar disorder allows researchers to study whether certain traits can affect how the condition progresses — specifically how severe the symptoms may become. Researchers have found there may be some personality traits that are more common in people with bipolar disorder. Varying ...

There are fewer more frightening or challenging psychiatric conditions for a family to face than psychosis, an extreme mental state in which impaired thinking and emotions cause a person to lose contact with reality. This could mean hearing or seeing things that aren't there (hallucinations), or believing things that aren't true (delusions). The illness most often associated with psychosis, schizophrenia, usually doesn't show up until very late adolescence or early adulthood. Recently, however, experts in the field have been working to identify high-risk kids who show symptoms that could serve as early warning signs of psychosis, and several academic centers have been set up to focus on this crucial period when it may be possible to change the trajectory of mental illness. Not all the kids who are identified with what experts call "prodromal" symptoms will progress, or "convert" to full-blown psychotic illness. But early intervention has been shown to ...

Bipolar disorder is a mental health condition that can cause significant mood changes. A person's energy levels, thoughts, feelings, and behaviors may be affected. When a bipolar partner is unwell, they may struggle to function as they would when they are well. This can create problems and impact the quality of life partners have established. These challenges can cause strain in a relationship for the person with the condition, as well as their spouse. It's common for someone with bipolar disorder to hurt or offend their partner or be controlling. Verywell / Julie Bang When living with a bipolar spouse, understanding the condition, recognizing and discussing the needs of both partners, and creating boundaries to care for each other can help manage a partner's bipolar disorder. Read on to learn about bipolar disorder, how it can affect a relationship, and ways to help a spouse living with the condition. Bipolar Disorder at a Glance ...

Bipolar Disorder: National Institutes of Health. (n.d.) "Bipolar Disorder." https://www.nimh.nih.gov/health/statistics/bipolar-disorder Cancer and BPD: Neuroscience and Biobehavioral Reviews . (2021.) "Risk of cancer in bipolar disorder and the potential role of lithium: International collaborative systematic review and meta-analyses." https://pubmed.ncbi.nlm.nih.gov/33831461/ Bipolar Disorder and Duration of Episodes: JAMA Psychiatry . (2010.) "Longitudinal Course of Bipolar I Disorder Duration of Mood Episodes." https://jamanetwork.com/journals/jamapsychiatry/fullarticle/210663 Substance Abuse and BPD: Drug and Alcohol Dependence . (2017.) "Alcohol use and bipolar disorders: Risk factors associated with their co-occurrence and sequence of onsets." https://www.sciencedirect.com/science/article/abs/pii/S0376871617303903 Substance Abuse and BPD: Substance Abuse Treatment, Prevention, and Policy . (2007.) "The prevalence and signifi...

A 31-year-old woman exhibited unusual symptoms of Cushing's disease following childbirth, but didn't show some of the disease's hallmark features, such as weight gain and fat accumulation. The woman's atypical symptoms, which included psychosis and severe muscle weakness, were accompanied by a challenging clinical course that led ultimately to her death. The case highlights "that an early diagnosis of Cushing's disease is important in pregnancy period for its prevalent fetal and maternal complications, and it should be treated early to optimize fetal and maternal outcomes," the researchers wrote in " A Case Report of Cushing's Disease Presenting With Psychosis and Muscle Weakness Postpartum ," which was published in the Journal of Investigative Medicine High Impact Case Reports.  Cushing's syndrome features abnormally high levels of the stress hormone cortisol, called hypercortisolism. Cushing's disease is a form of Cushi...

Psychosis occurs when a person has a break from reality which includes symptoms like delusions, hallucinations, and disordered thinking. These disruptive thoughts and sensory experiences make it hard for them to distinguish what is real from what is not. Approximately three in 100 people will experience an episode of psychosis in their lifetime. The experience of psychosis is unique to each person. Psychosis is not a condition on its own. Rather, it's a symptom of several mental health disorders, including psychotic disorders. Psychosis can also be a response to brain changes, traumatic events, injuries, or substance use. This article will cover the types of psychosis and how they are diagnosed and treated. FollowTheFlow / Getty Images Definition of Psychosis According to the American Psychiatric Association (APA) and the World Health Organization (WHO), psychosis is defined by the experience of having hallucinations, delus...

October 26, 2023 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . " data-action="subscribe"> Subscribe Added to email alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Back to Healio Key takeaways: Evenamide was associated with clinically significant improvements in treatment-resistant schizophrenia at 6 months. The investigational drug is intende...

Schizophrenia is a chronic psychiatric disorder that affects how a person thinks, feels, and behaves. Common early signs of schizophrenia vary by age group and include: Young children:  Delayed development Older kids and teens:  Depression, isolation, behavioral problems (e.g., stealing) or changes (e.g., bizarre or unusual thoughts or actions), and trouble focusing Adults:  Restlessness, anxiety, low energy, not taking care of oneself (e.g., personal hygiene), decrease in work performance, suicidal thoughts, and social withdrawal It is estimated that schizophrenia affects less than 1% of adults worldwide. Schizophrenia usually develops slowly, with early warning signs starting before the first severe episode. Knowing these warning signs can help a healthcare provider diagnose schizophrenia sooner and make sure that a person living with the condition gets the care and support that they need. Westend61 / Getty images ...